What do you know about Hysingla ER?
Zohydro ER is a prescription medication that contains hydrocodone bitartrate, an opioid analgesic.Unlike immediate-release formulations, Zohydro ER provides a controlled release of hydrocodone, which helps in managing chronic pain over a 24-hour period with a single dose.
Key Features :
- Opioid Analgesic: Hydrocodone, the active ingredient, works by altering the way the brain and nervous system respond to pain.
- Extended-Release Formulation: It is designed for once-daily administration and provides a sustained release of hydrocodone throughout the day.
- Abuse-Deterrent Properties: Zohydro ER has features intended to make it harder to abuse, such as making it difficult to crush, break, or dissolve, which helps in deterring abuse through snorting or injection.
- Indicated for Chronic Pain: It is prescribed for patients who need continuous, long-term opioid treatment for pain management, typically in cases where other pain management treatments are ineffective or not tolerated.
Side Effects:
- Common side effects include nausea, constipation, dizziness, drowsiness, and headaches.
- Serious risks include respiratory depression, addiction, abuse, and overdose, especially if misused.
Warnings:
- Boxed Warning: Zohydro ER carries a black box warning due to the risks of addiction, abuse, misuse, and life-threatening respiratory depression. It also warns against accidental ingestion, especially by children, which can be fatal.
- Interaction with Other Substances: Concurrent use with other central nervous system depressants, such as alcohol, benzodiazepines, or other opioids, can increase the risk of respiratory depression, overdose, and death.
- Tolerance and Dependence: Long-term use can lead to physical dependence and tolerance, meaning higher doses may be needed over time to achieve the same pain relief, which can increase risks.
It is essential for patients to follow their doctor’s instructions carefully when using Zohydro ER, both to manage pain effectively and to minimize risks of side effects and abuse.
Benefits:
The benefits of it primarily relate to its ability to manage chronic, severe pain while offering specific advantages due to its extended-release formulation and abuse-deterrent properties. Here are the key benefits:
1. Reduced Dosing Frequency
- Once-Daily Dosing: Its extended-release formulation allows patients to take the medication once per day, improving convenience and compliance, especially compared to short-acting opioids that may require multiple doses throughout the day.
2. Abuse-Deterrent Formulation
- Harder to Misuse: The abuse-deterrent properties make it more difficult to crush, break, or dissolve the tablet, reducing the potential for abuse via snorting or injection. This feature helps mitigate the risk of misuse that is common with opioid medications.
- Safety: The abuse-deterrent formulation is beneficial for patients at risk of opioid abuse or in households where others may be at risk of misuse.
3. Consistent Drug Levels
- Steady Hydrocodone Levels: The extended-release mechanism provides a more stable and consistent release of hydrocodone into the bloodstream, which can lead to fewer peaks and troughs in pain control, minimizing breakthrough pain and reducing the need for additional “rescue” pain medication.
4. Decreased Risk of End-of-Dose Failure
- Longer Duration of Action: This reduces the likelihood of end-of-dose failure, which happens when pain returns before the next dose of medication is due. This is a frequent issue with short-acting opioids.
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