What do you know about Fetzima?

Fetzima mechanism of action is the brand name for the drug levomilnacipran, an antidepressant primarily used to treat major depressive disorder (MDD). It belongs to a class of medications called serotonin-norepinephrine reuptake inhibitors (SNRIs), which work by increasing the levels of two neurotransmitters in the brain: serotonin and norepinephrine. These neurotransmitters play a key role in regulating mood and emotions, and their imbalance is often associated with depression.

Key Points About Fetzima:

1. Mechanism of Action: Fetzima mechanism of action inhibits the reuptake of serotonin and norepinephrine, leading to increased levels of these chemicals in the brain, which can help alleviate symptoms of depression. It is more norepinephrine-focused than some other SNRIs, meaning it has a stronger effect on norepinephrine compared to serotonin.
2. Approved Use:
   • Primarily approved for the treatment of major depressive disorder (MDD).
3. Dosage: Fetzima mechanism of action is available in extended-release capsules, typically taken once a day.
4. Side Effects: Common side effects of Fetzima include:
   • Nausea
   • Increased heart rate (tachycardia)
   • Dizziness
   • Dry mouth
   • Constipation
   • Sweating
   • Urinary hesitancy

   Like other antidepressants, it can also increase the risk of suicidal thoughts in young adults, particularly when starting the medication.

5. Warnings and Precautions:
   • Stopping Fetzima abruptly can lead to withdrawal symptoms, so it’s important to taper off the medication under medical supervision if needed.
6. Interactions:
   • Fetzima mechanism of action can interact with other medications that affect serotonin, leading to a risk of serotonin syndrome, a potentially dangerous condition.
7. Effectiveness: Studies have shown that Fetzima is effective in reducing the symptoms of MDD, and it may be particularly beneficial for individuals who have low energy or psychomotor retardation as part of their depressive symptoms.