Description

What do you know about Indomethacin?

Indomethacin dose is a nonsteroidal anti-inflammatory drug (NSAID) primarily used to reduce inflammation, pain, and fever.

Uses:

• Rheumatoid arthritis: Used to reduce inflammation and joint pain.
• Osteoarthritis: Effective for reducing pain and swelling in joints.
• Ankylosing spondylitis: Commonly prescribed for this type of spinal arthritis.
• Acute gouty arthritis: Frequently used to manage the pain and inflammation of gout flare-ups.
• Other inflammatory conditions: Can be used in conditions like bursitis or tendinitis.

Mechanism of Action:

• COX Inhibition: Indomethacin dose inhibits both COX-1 and COX-2 enzymes, which are responsible for synthesizing prostaglandins that lead to inflammation, pain, and fever. By reducing these prostaglandins, indomethacin helps alleviate these symptoms.

Forms of Indomethacin:

• Oral tablets/capsules: These are taken by mouth and are the most common form.
• Suppositories: Used rectally, especially in cases where the oral route is not ideal.
• Topical formulations: Less commonly used, but sometimes applied locally for pain relief.

Common Side Effects:

• Gastrointestinal issues: Indomethacin dose can cause stomach pain, nausea, vomiting, or more severe effects like ulcers or gastrointestinal bleeding, especially with long-term use.
• Cardiovascular risks: Long-term use has been associated with an increased risk of heart attack or stroke, similar to other NSAIDs.

Additional information