What do you know about Orlistat?

Orlistat tablet is a medication primarily used to treat obesity by helping with weight loss or to prevent regaining weight already lost. It works by inhibiting the absorption of fats from the diet, thereby reducing calorie intake. Orlistat is available in both prescription form (under the brand name Xenical) and over-the-counter (OTC) form (as Alli in some regions, with a lower dosage).

How Orlistat Works:

Orlistat tablet inhibits lipases, which are enzymes that break down fats in the intestines. When these enzymes are blocked, about 25–30% of the fat consumed in food is not absorbed and is instead excreted in the stool.

Dosage:

• Prescription (Xenical): 120 mg three times a day with each main meal that contains fat.
• OTC (Alli): 60 mg three times a day with meals.

Effectiveness:

• Orlistat tablet, combined with a reduced-calorie, low-fat diet and exercise, can result in modest weight loss. Studies suggest that over the course of a year, people taking orlistat may lose an additional 5-10% of their body weight compared to those relying on diet and exercise alone.
• Orlistat may also help reduce the risk of regaining weight after initial weight loss.

Side Effects:

The most common side effects are related to the digestive system, as the unabsorbed fat is excreted:

• Oily or fatty stools
• Frequent or urgent bowel movements
• Flatulence
• Abdominal discomfort

Precautions:

• Vitamins: Since orlistat inhibits fat absorption, it can also reduce the absorption of fat-soluble vitamins (A, D, E, and K).
• Drug Interactions: Orlistat may interfere with certain medications, such as those for diabetes, thyroid problems, or organ transplant (e.g., cyclosporine).

Contraindications:

Orlistat tablet is not suitable for everyone. It should not be used by individuals with:

• Chronic malabsorption syndrome
• Cholestasis (a liver condition that impairs bile flow)
• Pregnant or breastfeeding women should avoid orlistat.