What do you know about Marplan ?

Marplan mechanism of action is the brand name for isocarboxazid, a medication classified as a monoamine oxidase inhibitor (MAOI). It is primarily used to treat depression, particularly in cases where other treatments (such as selective serotonin reuptake inhibitors or tricyclic antidepressants) have been ineffective.

Key Information about Marplan (Isocarboxazid):

• Mechanism of Action: Marplan mechanism of action works by inhibiting the activity of the enzyme monoamine oxidase (MAO) in the brain. MAO is responsible for breaking down neurotransmitters like serotonin, norepinephrine, and dopamine. By inhibiting this enzyme, Marplan increases the levels of these neurotransmitters, which can help improve mood and alleviate symptoms of depression.
• The usual maintenance dose ranges from 40 to 60 mg per day, divided into two doses.
• Side Effects: Common side effects of Marplan may include:
  • Dizziness
  • Dry mouth
  • Insomnia
  • Weight gain
  • Orthostatic hypotension (low blood pressure when standing up)

  Serious side effects could include:

  • Hypertensive crisis (a dangerous increase in blood pressure, particularly if certain foods or drugs are consumed)
  • Liver problems
  • Serotonin syndrome (if combined with other serotonergic agents)
• Dietary Restrictions: One of the key concerns with Marplan, like other MAOIs, is its interaction with tyramine, a substance found in certain foods. Tyramine can cause a hypertensive crisis (sudden, dangerous rise in blood pressure) if consumed in large amounts. Patients on Marplan are advised to avoid foods rich in tyramine, including aged cheeses, fermented foods, cured meats, and some alcoholic beverages (especially beer and red wine).
• Drug Interactions: Marplan mechanism of action can interact dangerously with a variety of medications, including:
  • Other antidepressants, particularly SSRIs, SNRIs, and other MAOIs
  • Over-the-counter decongestants
  • Certain pain medications like tramadol
  • Medications that affect serotonin, dopamine, or norepinephrine levels

  Due to the risk of serious interactions, doctors often require a washout period when switching between MAOIs and other antidepressants.

Considerations:

Marplan mechanism of action is often prescribed with caution due to the potential for severe side effects and dietary/drug restrictions. However, for individuals with treatment-resistant depression, it can be a life-changing medication.