What do you know about Piroxicam?

Piroxicam Injection is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and swelling associated with various conditions like arthritis, including rheumatoid arthritis and osteoarthritis. Here are some key points about piroxicam:

Mechanism of Action:

Piroxicam Injection works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins—substances that contribute to inflammation, pain, and fever. By blocking prostaglandin production, piroxicam helps reduce symptoms of pain and inflammation.

Uses:

• Osteoarthritis: To relieve joint pain, stiffness, and swelling.
• Rheumatoid Arthritis: To manage inflammation and pain.
• Acute musculoskeletal injuries: Sometimes prescribed to treat short-term pain from strains, sprains, or muscle injuries.
• Post-surgical pain: Occasionally used for pain relief after surgery.

Dosage:

Piroxicam Injection is available in tablet or capsule form and is typically taken once daily. The usual dose for adults is 20 mg per day, either as a single dose or divided into smaller doses. The dose may vary depending on the condition being treated.

Side Effects:

Common side effects may include:

• Stomach upset or discomfort
• Nausea
• Dizziness
• Heartburn
• Diarrhea or constipation

Serious side effects, though less common, include:

• Stomach ulcers or bleeding
• Increased risk of cardiovascular events like heart attack or stroke, especially with long-term use
• Kidney damage
• Liver problems

Precautions:

• Gastrointestinal Issues: Piroxicam Injection, like other NSAIDs, can cause or worsen stomach ulcers and bleeding, especially in older adults or those with a history of gastrointestinal problems.
• Heart Risks: Prolonged use or high doses can increase the risk of cardiovascular events.
• Allergic Reactions: Some people may experience serious allergic reactions like difficulty breathing, swelling, or severe rash.

Interactions:

Piroxicam Injection may interact with other medications, including:

• Blood thinners (like warfarin)
• Other NSAIDs (like ibuprofen or aspirin)
• ACE inhibitors or diuretics (used to treat high blood pressure)
• Certain antidepressants (SSRIs, which increase the risk of bleeding)