What do you know about Imipramine?

Imipramine tablet is a tricyclic antidepressant (TCA) primarily used to treat major depressive disorder and, in some cases, anxiety disorders. It was one of the first antidepressants discovered and is known for its efficacy in alleviating depressive symptoms. Here are some key points about imipramine:

1. Mechanism of Action: Imipramine tablet works by inhibiting the reuptake of norepinephrine and serotonin in the brain, which helps to elevate mood and relieve depression.
   • Panic disorder
   • Nocturnal enuresis (bedwetting) in children
   • Chronic pain syndromes (off-label)
2. Side Effects: Common side effects can include:
   • Dry mouth
   • Drowsiness
   • Weight gain
   • Constipation
   • Blurred vision
   • Dizziness

   More serious side effects may include heart issues, seizures, and increased risk of suicidal thoughts, especially in young adults.

3. Drug Interactions: Imipramine tablet can interact with various medications, including other antidepressants, anticholinergics, and certain antihypertensives, so it’s important for patients to inform their healthcare provider about all medications they are taking.
4. Withdrawal: Discontinuing imipramine suddenly can lead to withdrawal symptoms, so it’s important to taper off the medication under a doctor’s guidance.