What do you know about Mefenamic acid?

Mefenamic acid for headache is a nonsteroidal anti-inflammatory drug (NSAID) used primarily to treat mild to moderate pain, especially pain associated with menstrual cramps (dysmenorrhea). It is also used to reduce inflammation and pain caused by conditions like arthritis, muscle sprains, and headaches.

Here are some key points about mefenamic acid:

Mechanism of Action:

• Mefenamic acid for headache works by inhibiting the production of prostaglandins, substances in the body that cause inflammation, pain, and fever. It achieves this by blocking the enzyme cyclooxygenase (COX), which is essential for prostaglandin synthesis.

Common Uses:

• Dysmenorrhea (painful menstrual periods)
• Musculoskeletal pain (e.g., muscle aches, sprains)
• Headaches or dental pain
• Arthritis pain (though not as common compared to other NSAIDs like ibuprofen or naproxen)

Dosage:

• The typical adult dose for pain management is 500 mg initially, followed by 250 mg every 6 hours as needed. It is usually prescribed for short-term use (no longer than 7 days) due to the risk of gastrointestinal side effects.

Side Effects:

• Gastrointestinal issues: stomach upset, nausea, diarrhea, or in severe cases, ulcers or bleeding.
• Renal issues: can impair kidney function, especially with long-term use or in people with existing kidney problems.
• Cardiovascular risk: like other NSAIDs, it may increase the risk of heart attack or stroke if used long-term or in high doses.

Contraindications:

• Should be avoided in people with a history of peptic ulcers, gastrointestinal bleeding, renal impairment, or heart disease.
• Not recommended during the third trimester of pregnancy as it can affect the fetal heart and kidney function.

Drug Interactions:

• Other NSAIDs (e.g., ibuprofen, aspirin): Increases the risk of adverse gastrointestinal and renal effects.
• Anticoagulants (e.g., warfarin): May increase the risk of bleeding.
• Diuretics: May reduce their effectiveness and increase the risk of kidney problems.