What do you know about oliceridine?

Benefits:

• Reduced Respiratory Depression: Due to its selective activation of the G-protein pathway and avoidance of the β-arrestin pathway, oliceridine is less likely to cause severe respiratory depression, one of the most dangerous side effects of opioid medications.
• Lower Incidence of Nausea and Vomiting: Many patients experience nausea and vomiting with traditional opioids, but oliceridine’s unique mechanism of action appears to reduce this risk, which can make it more tolerable for patients, particularly in post-surgical recovery.
• Effective for Acute Pain Management: Oliceridine provides potent pain relief comparable to morphine, making it useful in situations where fast-acting and strong pain management is necessary, such as post-operative care or acute injury settings.
• Faster Onset and Offset: Oliceridine has a rapid onset and shorter duration of action compared to some other opioids, allowing for more flexible dosing and making it easier to adjust pain management in real-time based on patient needs.
• Potentially Lower Risk of Constipation: While constipation is a common opioid side effect, studies suggest that oliceridine may result in less constipation compared to traditional opioids, likely due to its different pathway activation.
• Less Sedation: Some data indicate that patients may experience less sedation with oliceridine than with other opioids, which could enhance patient comfort and recovery, especially in a hospital setting.